- Dr. Mezgebu Silamsaw Asres
- +251921576259
- Mezgebu.silamsaw@uog.edu.et
- Director of CTC
Vision
To be the leading clinical trial center in Ethiopia 2031.
Mission
The mission of CTC is to conduct innovative and high-quality clinical trials, provide short term and long-term research trainings, and solve health problems.
Objectives
- Conduct, support and facilitate clinical trials
- Provide capacity building
- Long-term and short-term Training
- Contribute for the advancement of knowledge
Major Initiatives and Function of the CTC
The UOG CTC will ultimately focus on clinical research, education, supervision of clinical trials, data management and external consultation
RESEARCH
The center will develop research methods and conduct high quality clinical trial. The center will be devoted to facilitating clinical studies while taking participants safety.
TRAINING
The center will advocate using evidence-based medicine for decision making through training and knowledge management. It will affiliate with higher educational institutes and other research centers. Health care workers at different level of the health system will be the key participants in the capacity building and will be equipped with knowledge and practice of clinical trials.
- Training on Clinical Trials
- Laboratory for MSC and PhD Students
SUPERVISION AND MONITORING
The center will supervise clinical trials in Ethiopia. It will review and evaluate study data for participant safety, study conduct and progress, and make recommendations to continuation, modification, or termination of the trial. The activities include
- Data for evidence of study-related adverse events.
- Assessment of adherence to the protocols
DATA MANAGEMENT
In the UoG clinical trial center, best practices will be adopted to ensure that data are reliable, complete, and accurate. This will be facilitated by the use of software application that maintain an audit trial and provide easy identification and resolution of data discrepancies. Suitable opensource software application (e.g. OpenClinica, openCDMS, TrialDB, or PhOSCo) will be downloaded for free and customized to the context of UoG clinical trial center. A review article (Krishnankutty B. et al, 2012) stated that the opensource applications are as similar as the commercial clinical data management software in terms of functionality.
Thematic areas
- COVID-19, other virological diseases including HIV
- Neglected tropical diseases including malaria
- Tuberculosis and bacterial infections
- Non communicable disease
- Traditional medicine
Ongoing projects
ANTICOV Clinical trial
Trial ID: PACTR202006537901307
Title: An open-label, multicenter, randomized, adaptive platform trial of the safety and efficacy of several therapies, including antiviral therapies, versus control in mild/moderate cases of COVID-19 (ANTICOV Trial)
PI: Dr. Mezgebu Silamsaw Asres
Status: Currently recruiting
Diabetes Mellitus and Spices study
Trial ID: PACTR202202640395224
Title: Improving blood sugar control through patients’ choice of evidence-based spices and foods with hypoglycemic effect – A pragmatic trial.
PI: Dr. Mezgebu Silamsaw Asres
Status: Currently recruiting
Collaborators
AHRI
The Armauer Hansen Research Institute (AHRI) was founded in 1970 through the initiative of the Norwegian and Swedish Save the Children organizations seconded by the Ministry of Health of Ethiopia. The Institute got its name from the Norwegian physician, Gerhard Henrik Armauer Hansen, who first described the leprosy bacillus (Mycobacterium leprae). AHRI was established as a biomedical research institute located next to the All Africa Leprosy Rehabilitation and Training Hospital (ALERT).
AHRI acknowledges receiving core-funding from Swedish International Development Cooperation Agency (Sida) and Norwegian Agency for Development Cooperation(Norad) in addition to Ethiopian Government contribution, which it uses to support among other things students’ research within the scope of the European & Developing Countries Clinical Trials Partnership (EDCTP) programme. These include epidemiological and social studies for characterization of poverty-related and neglected diseases.
LRTC
Established in 2004 the Leishmaniasis Research and Treatment Center provides treatment services to patients, carries out GCP compliant clinical trial clinical trial research on Visceral Leishmaniasis. The Center also has a 24-bed ward and laboratory. Researches are sponsored by Drugs for Neglected Diseases initiative (DNDi), Switzerland a collaborative, patients’ needs-driven, non-profit drug research and development (R&D) organization that is developing new treatments for Neglected Diseases and the Institute of Tropical Medicine (ITM) in Antwerp, Belgium.